What do you do when your female Beagle just does not seem interested in the male? Most male dogs (un-neutered) will breed absolutely at any time. There will be a few exceptions when a male is just not interested in the female dog.
A female, of course will only breed when in heat. A female dog will go into heat about twice a year. However, there is a big misconception regarding this: Once showing the signs of heat, the dog will most likely not immediately breed the first day. For some dogs it is over 2 weeks after the signs.
The average time to allow for breeding is anywhere between 1 and 17 days. Every dog is different. The good news is that every dog has a pattern; she will raise her tail (known as flagging) when she is receptive. Once you figure out what your Beagle's pattern is, you will know exactly which days she is ready.
Once you know you do not wish to breed your Beagle any more, you should have her spayed. A Beagle that is not spayed in her later years of life may have severe complications of the uterus. For pet owners, it is best for your dog to not breed her and to have her spayed as early as possible. Spaying even before the first heat eliminates the risk of ovarian cancer and greatly reduces the risks of infection.